Cryptocaryols A and B: Total Syntheses, Stereochemical Revision, Structure Elucidation, and Structure鈥揂ctivity Relationship
详细信息 查看全文
- 作者：Yanping Wang ; George A. O鈥橠oherty
- 刊名：The Journal of the American Chemical Society
- 出版年：2013
- 出版时间：June 26, 2013
- 年：2013
- 卷：135
- 期：25
- 页码：9334-9337
- 全文大小：336K
- 年卷期：v.135,no.25(June 26, 2013)
- ISSN：1520-5126
文摘
The first total syntheses and structural elucidation of cryptocaryol A and cryptocaryol B were achieved in 23 and 25 linear steps, respectively. The synthesis relied on the use of a key pseudo-Cs symmetric pentaol intermediate, which in a stereochemically divergent manner was converted into either enantiomer as well as diastereomers. This synthetic effort enabled the first structure鈥揳ctivity relationships of this class of PDCD4 stabilizing natural products.