Generic Top-Functionalization of Patterned Antifouling Zwitterionic Polymers on Indium Tin Oxide

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• 作者：Yan Li ; Marcel Giesbers ; Marieke Gerth ; Han Zuilhof
• 刊名：Langmuir
• 出版年：2012
• 出版时间：August 28, 2012
• 年：2012
• 卷：28
• 期：34
• 页码：12509-12517
• 全文大小：517K
• 年卷期：v.28,no.34(August 28, 2012)
• ISSN：1520-5827

文摘

This paper presents a novel surface engineering approach that combines photochemical grafting and surface-initiated atom transfer radical polymerization (SI-ATRP) to attach zwitterionic polymer brushes onto indium tin oxide (ITO) substrates. The photochemically grafted hydroxyl-terminated organic layer serves as an excellent platform for initiator attachment, and the zwitterionic polymer generated via subsequent SI-ATRP exhibits very good antifouling properties. Patterned polymer coatings can be obtained when the surface with covalently attached initiator was subjected to photomasked UV-irradiation, in which the C鈥揃r bond that is present in the initiator was broken upon exposure to UV light. A further, highly versatile top-functionalization of the zwitterionic polymer brush was achieved by a strain-promoted alkyne鈥揳zide cycloaddition, without compromising its antifouling property. The attached bioligand (here: biotin) enables the specific immobilization of target proteins in a spatially confined fashion, pointing to future applications of this approach in the design of micropatterned sensing platforms on ITO substrates.