Structural Features of a New Dinuclear Platinum(II) Complex with Significant Antiproliferative Activity

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• 作者：Luigi Messori ; Jiajiu Shaw ; Mercedes Camalli ; Pasquale Mura ; and Giordana Marcon
• 刊名：Inorganic Chemistry
• 出版年：2003
• 出版时间：October 6, 2003
• 年：2003
• 卷：42
• 期：20
• 页码：6166 - 6168
• 全文大小：47K
• 年卷期：v.42,no.20(October 6, 2003)
• ISSN：1520-510X

文摘

A novel dinuclear platinum(II) complex, [Pt₂-N,N'-bis(2-dimethylaminoethyl oxamide)Cl₄], showing peculiar structural features, hasbeen prepared and characterized. X-ray diffraction data reveal thatthe two platinum ions are simultaneously bound to the N,N'-bis(2-dimethylaminoethyl) oxamide ligand, on opposite sides. Thecoordination environment of both platinum centers is square planar,with identical NOCl₂ donor sets. The complex is poorly solublewithin a physiological buffer but moderately soluble in DMSO.Preliminary in vitro studies point out that this dinuclear platinumcomplex exhibits significant growth-inhibiting properties on a panelof cultured human tumor cell lines, although less pronounced thanthose of cisplatin.