Microbial Transformations of the Taxan Ring of 10-DAB by Some Strains of the Fungus Curvularia lunata: Formation of the Bis-abeotaxanes Wallifoliol and 4-Deacylwallifoliol

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• 作者：Alberto Arnone ; Adriana Bava ; Giovanni Fronza ; Luciana Malpezzi ; Gianluca Nasini
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：June 25, 2010
• 年：2010
• 卷：73
• 期：6
• 页码：1049-1052
• 全文大小：139K
• 年卷期：v.73,no.6(June 25, 2010)
• ISSN：1520-6025

文摘

The fermentation of 10-deacetylbaccatine III (10-DAB) (1) with Curvularia lunata afforded 4-deacylwallifoliol (4) and wallifoliol (5), the only natural taxoid with the unusual 5/6/6/6/4 ring system. The X-ray structure of compound 4 is reported. The skeletal rearrangements induced by the microbial enzymatic systems are also discussed.