文摘
Here we report a redox-responsive host鈥揼uest complex between a new water-soluble pillar[5]arene (WP5) and a paraquat derivative. Compared with the neutral form of the paraquat derivative that binds WP5 weakly, its dication form binds WP5 much more strongly. Furthermore, we utilize this new water-soluble redox-responsive molecular recognition motif to construct the first pillararene-based amphiphilic macromolecular [2]pseudorotaxane, which self-assembles into redox-responsive polymeric vesicles in water. Such pillararene-based supramolecular vesicles were further used to construct a drug delivery system to encapsulate and controlled release DOX路HCl, an anticancer drug. The uptake of these DOX路HCl-loaded supramolecular vesicles by cancer cells was studied with confocal laser scanning microscopy. Meanwhile, DOX路HCl-loaded supramolecular vesicles showed anticancer activity in vitro comparable to free DOX路HCl under the examined conditions.