Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery
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- 作者：John G. Hardy ; Eneko Larrañeta ; Ryan F. Donnelly ; Niamh McGoldrick ; Katarzyna Migalska ; Maelíosa T. C. McCrudden ; Nicola J. Irwin ; Louise Donnelly ; Colin P. McCoy
- 刊名：Molecular Pharmaceutics
- 出版年：2016
- 出版时间：March 7, 2016
- 年：2016
- 卷：13
- 期：3
- 页码：907-914
- 全文大小：413K
- ISSN：1543-8392
文摘
We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 h). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in “on-demand” delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.