Enantioselective Synthesis of 伪-Tri- and 伪-Tetrasubstituted Allylsilanes by Copper-Catalyzed Asymmetric Allylic Substitution of Allyl Phosphates with Silylboronates

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• 作者：Momotaro Takeda ; Ryo Shintani ; Tamio Hayashi
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：May 17, 2013
• 年：2013
• 卷：78
• 期：10
• 页码：5007-5017
• 全文大小：416K
• 年卷期：v.78,no.10(May 17, 2013)
• ISSN：1520-6904

文摘

A copper/N-heterocyclic carbene-catalyzed asymmetric allylic substitution of allyl phosphates with a silylboronate has been developed to give highly enantioenriched allylsilanes. High regioselectivity has been achieved by employing NaOH as the base, and this catalyst system is effective for both 纬-mono- and disubstituted allyl phosphates.