Epoxyphomalin A and B, Prenylated Polyketides with Potent Cytotoxicity from the Marine-Derived Fungus Phoma sp.

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• 作者：Ietidal E. Mohamed ; Harald Gross ; Alexander Pontius ; Stefan Kehraus ; Anja Krick ; Gerhard Kelter ; Armin Maier ; Heinz-Herbert Fiebig ; Gabriele M. Knig
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：November 5, 2009
• 年：2009
• 卷：11
• 期：21
• 页码：5014-5017
• 全文大小：131K
• 年卷期：v.11,no.21(November 5, 2009)
• ISSN：1523-7052

文摘

Chemical investigation of a strain of the marine-derived fungus Phoma sp. has led to the discovery of epoxyphomalin A (1) and B (2), two new prenylated polyketides with unusual structural features. Epoxyphomalin A (1) showed superior cytotoxicity at nanomolar concentrations toward 12 of a panel of 36 human tumor cell lines. In COMPARE analyses, the observed cytotoxic selectivity pattern of 1 did not correlate with those of reference anticancer agents with known mechanisms of action.