Biscarpamontamines A and B, an Aspidosperma−Iboga Bisindole Alkaloid and an Aspidosperma−Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa
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- 作者：Kazumasa Zaima ; Tomoko Hirata ; Takahiro Hosoya ; Yusuke Hirasawa ; Koichiro Koyama ; Abdul Rahman ; Idha Kusumawati ; Noor Cholies Zaini ; Motoo Shiro ; Hiroshi Morita
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：September 25, 2009
- 年：2009
- 卷：72
- 期：9
- 页码：1686-1690
- 全文大小：298K
- 年卷期：v.72,no.9(September 25, 2009)
- ISSN：1520-6025
文摘
Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma−iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma−aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.