Eucophylline, a Tetracyclic Vinylquinoline Alkaloid from Leuconotis eugenifolius
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- 作者：Jun Deguchi ; Tomokazu Shoji ; Alfarius E. Nugroho ; Yusuke Hirasawa ; Takahiro Hosoya ; Osamu Shirota ; Khalijah Awang ; A. Hamid A. Hadi ; Hiroshi Morita
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：October 22, 2010
- 年：2010
- 卷：73
- 期：10
- 页码：1727-1729
- 全文大小：153K
- 年卷期：v.73,no.10(October 22, 2010)
- ISSN：1520-6025
文摘
Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.