Cassiarins C−E, Antiplasmodial Alkaloids from the Flowers of Cassia siamea

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• 作者：Shiori Oshimi ; Jun Deguchi ; Yusuke Hirasawa ; Wiwied Ekasari ; Aty Widyawaruyanti ; Tutik Sri Wahyuni ; Noor Cholies Zaini ; Osamu Shirota ; Hiroshi Morita
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：October 23, 2009
• 年：2009
• 卷：72
• 期：10
• 页码：1899-1901
• 全文大小：106K
• 年卷期：v.72,no.10(October 23, 2009)
• ISSN：1520-6025

文摘

Three new alkaloids, cassiarins C−E (1−3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1−4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).