Alsmaphorazines A and B, Novel Indole Alkaloids from Alstonia pneumatophora
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- 作者：Koichiro Koyama ; Yusuke Hirasawa ; Alfarius Eko Nugroho ; Takahiro Hosoya ; Teh Chin Hoe ; Kit-Lam Chan ; Hiroshi Morita
- 刊名：Organic Letters
- 出版年：2010
- 出版时间：September 17, 2010
- 年：2010
- 卷：12
- 期：18
- 页码：4188-4191
- 全文大小：179K
- 年卷期：v.12,no.18(September 17, 2010)
- ISSN：1523-7052
文摘
Two novel indole alkaloids, alsmaphorazines A and B, were isolated from the leaves of Alstonia pneumatophora (Apocynaceae), and their structures were determined on the basis of the 2D NMR and MS spectral analysis. These alkaloids possessed a new skeleton consisting of an 1,2-oxazinane and an isoxazolidine chromophore. The absolute configuration of alsmaphorazine B was determined by using CD spectral analysis. Alsmaphorazine A inhibited the NO production in the LPS-stimulated J774.1 cells dose-dependently without affecting the cell viability.