Bisnicalaterines B and C, Atropisomeric Bisindole Alkaloids from Hunteria zeylanica, Showing Vasorelaxant Activity
详细信息 查看全文
- 作者：Yusuke Hirasawa ; Mayumi Hara ; Alfarius E. Nugroho ; Masatomo Sugai ; Kazumasa Zaima ; Nobuo Kawahara ; Yukihiro Goda ; Khalijah Awang ; A. Hamid A. Hadi ; Marc Litaudon ; Hiroshi Morita
- 刊名：Journal of Organic Chemistry
- 出版年：2010
- 出版时间：June 18, 2010
- 年：2010
- 卷：75
- 期：12
- 页码：4218-4223
- 全文大小：828K
- 年卷期：v.75,no.12(June 18, 2010)
- ISSN：1520-6904
文摘
Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta.