Total Synthesis of A Novel Tetracyclic Alkaloid, Cassiarin F from the Flowers of Cassia siamea

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• 作者：Jun Deguchi ; Tomoe Hirahara ; Shiori Oshimi ; Yusuke Hirasawa ; Wiwied Ekasari ; Osamu Shirota ; Toshio Honda ; Hiroshi Morita
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：13
• 期：16
• 页码：4344-4347
• 全文大小：722K
• 年卷期：v.13,no.16(August 19, 2011)
• ISSN：1523-7052

文摘

A novel alkaloid, cassiarin F (1), which showed potent antiplasmodial activity against Plasmodium falciparum in vitro, was isolated from the flowers of Cassia siamea, and its structure was elucidated on the basis of 2D NMR analyses. A total synthesis of 1 was also achieved by employing the Suzuki coupling constructing biaryl unit, nucleophilic aromatic substitution, and Houben鈥揌oesch type ring construction as key steps.