Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclization, and Oxidation
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- 作者：Yusuke Ohta ; Yushi Kubota ; Tsuyoshi Watabe ; Hiroaki Chiba ; Shinya Oishi ; Nobutaka Fujii ; Hiroaki Ohno
- 刊名：Journal of Organic Chemistry
- 出版年：2009
- 出版时间：August 21, 2009
- 年：2009
- 卷：74
- 期：16
- 页码：6299-6302
- 全文大小：761K
- 年卷期：v.74,no.16(August 21, 2009)
- ISSN：1520-6904
文摘
A novel copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline-fused polycyclic compounds, through four-component coupling, cyclization, and oxidation, has been developed. A Mannich-type reaction of 2-ethynylbenzaldehyde with paraformaldehyde and a secondary amine followed by treatment with a diamine component gave tricyclic isoquinolines through cascade cyclization and oxidation. Construction of fused isoquinolines of various ring sizes is also presented.