Method for the Efficient Synthesis of Highly-Substituted Oxetan- and Azetidin-, Dihydrofuran- and Pyrrolidin-3-ones and Its Application to the Synthesis of (卤)-Pseudodeflectusin

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• 作者：Tomohiro Maegawa ; Kazuki Otake ; Keiichi Hirosawa ; Akihiro Goto ; Hiromichi Fujioka
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 21, 2012
• 年：2012
• 卷：14
• 期：18
• 页码：4798-4801
• 全文大小：270K
• 年卷期：v.14,no.18(September 21, 2012)
• ISSN：1523-7052

文摘

Highly substituted four- and five-membered heterocycles were prepared starting with O,P- and N,P-acetals by using a one-pot method involving base induced cyclization and a Horner鈥揥adsworth鈥揈mmons (HWE) olefination reaction. Divergent synthesis of various heterocycles was achieved by using this method and transformations of the alkenyl group in the products of these processes were exemplified. Finally, a short and efficient synthesis of (卤)-pseudodeflectusin based on the new methodology was achieved.