Antioxidant Effects of Chromium Supplementation with Type 2 Diabetes Mellitus and Euglycemic Subjects
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- 作者：Hsing-Hsien Cheng ; Ming-Hoang Lai ; Wen-Chi Hou ; and Chen-Ling Huang
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2004
- 出版时间：March 10, 2004
- 年：2004
- 卷：52
- 期：5
- 页码：1385 - 1389
- 全文大小：41K
- 年卷期：v.52,no.5(March 10, 2004)
- ISSN：1520-5118
文摘
To determine the effects of chromium (Cr) supplementations on oxidative stress of type 2 diabetesand euglycemic (EU) subjects, adult having HbA1C values of <6.0% (EU), 6.8-8.5% (mildlyhyperglycemic, MH), and >8.5% (severely hyperglycemic, SH) were supplemented for 6 monthswith 1000 
g/day of Cr (as Cr yeast) or with a placebo. In the beginning, the levels of the plasma Crin the MH and SH groups were 25-30% lower than those of the EU subjects. The values ofthiobarbituric acid reactive substances (TBARS) and total antioxidative status (TAS) of the MH andSH groups were significantly higher than those of the EU ones. Following supplementations, thelevels of plasma TBARS in the Cr groups of MH and SH groups were significantly decreased (theinverse was found in the EU) and showed no significant changes in the placebo group. The levels ofplasma TAS in the Cr groups of EU and MH were significantly decreased (the inverse was found inthe SH) and showed no significant changes in the placebo group. No significant difference was foundin the antioxidant enzyme (superoxide dismutase, glutathione peroxidase, catalase) activities duringsupplementations. These data suggest that Cr supplementation was an effective treatment strategyto minimize increased oxidative stress in type 2 diabetes mellitus patients whose HbA1C level was>8.5%, and the Cr in EU groups might act as a prooxidant.Keywords: Antioxidants; chromium; diabetes; total antioxidative status (TAS); thiobarbituric acidreactive substances (TBARS)
g/day of Cr (as Cr yeast) or with a placebo. In the beginning, the levels of the plasma Crin the MH and SH groups were 25-30% lower than those of the EU subjects. The values ofthiobarbituric acid reactive substances (TBARS) and total antioxidative status (TAS) of the MH andSH groups were significantly higher than those of the EU ones. Following supplementations, thelevels of plasma TBARS in the Cr groups of MH and SH groups were significantly decreased (theinverse was found in the EU) and showed no significant changes in the placebo group. The levels ofplasma TAS in the Cr groups of EU and MH were significantly decreased (the inverse was found inthe SH) and showed no significant changes in the placebo group. No significant difference was foundin the antioxidant enzyme (superoxide dismutase, glutathione peroxidase, catalase) activities duringsupplementations. These data suggest that Cr supplementation was an effective treatment strategyto minimize increased oxidative stress in type 2 diabetes mellitus patients whose HbA1C level was>8.5%, and the Cr in EU groups might act as a prooxidant.Keywords: Antioxidants; chromium; diabetes; total antioxidative status (TAS); thiobarbituric acidreactive substances (TBARS)