Uptake, Elimination, and Biotransformation of 17伪-Ethinylestradiol by the Freshwater Alga Desmodesmus subspicatus

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• 作者：Hanna Maja Maes ; Sibylle Xenia Maletz ; Hans Toni Ratte ; Juliane Hollender ; Andreas Schaeffer
• 刊名：Environmental Science & Technology
• 出版年：2014
• 出版时间：October 21, 2014
• 年：2014
• 卷：48
• 期：20
• 页码：12354-12361
• 全文大小：372K
• ISSN：1520-5851

文摘

Bioconcentration and transformation of the potent and persistent xeno-estrogen 17伪-ethinylestradiol (EE2) by organisms at the basis of the food web have received only little research attention. In this study, uptake, elimination, and biotransformation of radiolabeled EE2 (¹⁴C-EE2) by the freshwater green alga Desmodesmus subspicatus were investigated. The alga highly incorporated radioactivity following ¹⁴C-EE2 exposure. Up to 68% of the test compound was removed from the medium by D. subspicatus within a rather short time period (72 h C_algae/C_water: 2200 L/kg wet weight). When the algae were transported to clear medium, a two-stage release pattern was observed with an initially quick elimination phase following slower clearance afterward. Interestingly, D. subspicatus brominated EE2 when bromide was available in the medium, a transformation process demonstrated to occur abiotically but not by algae. The consequence of the presence of more hydrophobic mono- and dibrominated EE2 in the environment remains to be further investigated, as these products were shown to have a lower estrogenic potency but are expected to have a higher bioaccumulation potential and to be more toxic than the mother compound.