Dynamic Kinetic Asymmetric Synthesis of Five Contiguous Stereogenic Centers by Sequential Organocatalytic Stetter and Michael鈭扐ldol Reaction: Enantioselective Synthesis of Fully Substituted Cyclopenta
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- 作者：Bor-Cherng Hong ; Nitin S. Dange ; Che-Sheng Hsu ; Ju-Hsiou Liao ; Gene-Hsiang Lee
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：March 18, 2011
- 年：2011
- 卷：13
- 期：6
- 页码：1338-1341
- 全文大小：719K
- 年卷期：v.13,no.6(March 18, 2011)
- ISSN：1523-7052
文摘
A synthesis of fully substituted cyclopentanes bearing a quaternary carbon center and five contiguous stereogenic centers has been achieved by sequential organocatalyzed Stetter and Michael鈭扐ldol reactions of heteroaromatic aldehydes, nitroalkenes, and 伪,尾-unsaturated aldehydes via the [1 + 2 + 2] annulation strategy with dynamic kinetic asymmetric transformation and excellent enantioselectivities (up to >99% ee).