Iridium-Catalyzed X−H Insertions of Sulfoxonium Ylides

详细信息    查看全文

• 作者：Ian K. Mangion ; Ikenna K. Nwamba ; Michael Shevlin ; Mark A. Huffman
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：August 20, 2009
• 年：2009
• 卷：11
• 期：16
• 页码：3566-3569
• 全文大小：164K
• 年卷期：v.11,no.16(August 20, 2009)
• ISSN：1523-7052

文摘

The unique reactivity of sulfoxonium ylides as a carbene source is described for a variety of X−H bond insertions, taking advantage of a simple, commercially available iridium catalyst. This method has applications in both intra- and intermolecular reactivity, including a practical ring-expansion strategy for lactams. The safety and stability of sulfoxonium ylides recommend them as preferable surrogates to traditional diazo ketones and esters.