Synthesis of the Tetracyclic Core (ABCE Rings) of Daphenylline
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- 作者：Bowen Fang ; Huaiji Zheng ; Changgui Zhao ; Peng Jing ; Huilin Li ; Xingang Xie ; Xuegong She
- 刊名：The Journal of Organic Chemistry
- 出版年：2012
- 出版时间：September 21, 2012
- 年：2012
- 卷：77
- 期：18
- 页码：8367-8373
- 全文大小：335K
- 年卷期：v.77,no.18(September 21, 2012)
- ISSN：1520-6904
文摘
A concise synthesis of the tetracyclic core (ABCE rings) of daphenylline has been accomplished involving a benzobicyclo[3.3.1] lactam as the key intermediate. This bridged bicyclic intermediate was efficiently constructed via a Br酶nsted acid promoted intramolecular Friedel鈥揅rafts type Michael addition of a 未-benzyl 伪,尾-unsaturated 未-lactam.