Synthetic Polymer Nanoparticles Conjugated with FimHA from E. coli Pili to Emulate the Bacterial Mode of Epithelial Internalization

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• 作者：Lily Yun Lin ; Kristin M. Tiemann ; Yali Li ; Jerome S. Pinkner ; Jennifer N. Walker ; Scott J. Hultgren ; David A. Hunstad ; Karen L. Wooley
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：March 7, 2012
• 年：2012
• 卷：134
• 期：9
• 页码：3938-3941
• 全文大小：292K
• 年卷期：v.134,no.9(March 7, 2012)
• ISSN：1520-5126

文摘

Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH_A through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.