Lajollamycins, Nitro Group-Bearing Spiro-尾-lactone-纬-lactams Obtained from a Marine-Derived Streptomyces sp.
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- 作者：Keebeom Ko ; So-Hyoung Lee ; Seong-Hwan Kim ; Eun-Hee Kim ; Ki-Bong Oh ; Jongheon Shin ; Dong-Chan Oh
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：September 26, 2014
- 年：2014
- 卷：77
- 期：9
- 页码：2099-2104
- 全文大小：325K
- ISSN：1520-6025
文摘
Lajollamycins (1鈥?b>4), each of which bears a spiro-尾-lactone-纬-lactam ring and a nitro-tetraene moiety, were obtained from a marine-derived Streptomyces strain isolated from the southern area of Jeju Island, Republic of Korea. The planar structures of the lajollamycins were elucidated on the basis of spectroscopic analyses by NMR, UV, IR, and MS. The absolute configuration of lajollamycin (1), the planar structure of which has been previously reported, was determined using J-based configuration analysis based on 1H鈥?sup>1H and 1H鈥?sup>13C coupling constants, as well as ROESY correlations, followed by the modified Mosher鈥檚 method. The absolute configurations of lajollamycins B鈥揇 (2鈥?b>4) were established by comparing their CD spectra with that of 1. The lajollamycins exhibited moderate inhibitory activity toward Candida albicans isocitrate lyase.