Natural Polypeptide-Based Supramolecular Nanogels for Stable Noncovalent Encapsulation

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• 作者：Keunsuk Kim ; Boram Bae ; Young Ji Kang ; Jwa-Min Nam ; Sebyung Kang ; Ja-Hyoung Ryu
• 刊名：Biomacromolecules
• 出版年：2013
• 出版时间：October 14, 2013
• 年：2013
• 卷：14
• 期：10
• 页码：3515-3522
• 全文大小：563K
• 年卷期：v.14,no.10(October 14, 2013)
• ISSN：1526-4602

文摘

Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction between positive surfactant micelles and negative polypeptides. Core鈥搒hell-like structures of supramolecular nanogels provide stable hydrophobic pockets that prevent simple diffusion of hydrophobic guest molecules, resulting in high encapsulation stability. The size of the supramolecular nanogels can be systematically controlled by varying the size of the surfactant micelles. Furthermore, noncovalently encapsulated dye molecules can be released in response to matrix metalloproteinases highly overexpressed in tumor tissues, potentially providing tumor-triggered targeting.