Peptide Nucleic Acid Synthesis by Novel Amide Formation

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• 作者：Hyunil Lee ; Jae Hoon Jeon ; Jong Chan Lim ; Hoon Choi ; Yeohong Yoon ; Sung Kee Kim
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：August 16, 2007
• 年：2007
• 卷：9
• 期：17
• 页码：3291 - 3293
• 全文大小：99K
• 年卷期：v.9,no.17(August 16, 2007)
• ISSN：1523-7052

文摘

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Synthesis of self-activated peptide nucleic acid (PNA) monomers and an efficient method for PNA synthesis using a benzothiazole-2-sulfonyl(Bts) group as an amine-protecting group as well as an acid-activating group are reported. Couplings were complete within 120 min, and thedeprotection was performed in 10 min. This Bts strategy provides a high purity PNA oligomer and is appropriate for large-scale synthesis. Theresults of the 15-mer PNA oligomer are described.