Access to the Surugatoxin Alkaloids: Chemo-, Regio-, and Stereoselective Oxindole Annulation

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• 作者：Meagan E. Hinze ; Jessica L. Daughtry ; Chad A. Lewis
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：80
• 期：22
• 页码：11258-11265
• 全文大小：570K
• ISSN：1520-6904

文摘

We report the synthesis of an aglycone of the surugatoxin family. The synthesis of this surugatoxin core was accomplished in 13 steps using a new oxindole annulation and late-stage enamine oxidation.