Kadcoccinic Acids A鈥揓, Triterpene Acids from Kadsura coccinea
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- 作者：Cheng-Qin Liang ; Yi-Ming Shi ; Wei-Guang Wang ; Zheng-Xi Hu ; Yan Li ; Yong-Tang Zheng ; Xiao-Nian Li ; Xue Du ; Jian-Xin Pu ; Wei-Lie Xiao ; Hong-Bin Zhang ; Han-Dong Sun
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：August 28, 2015
- 年：2015
- 卷：78
- 期：8
- 页码：2067-2073
- 全文大小：333K
- ISSN：1520-6025
文摘
Eleven triterpene acids including 10 new compounds (kadcoccinic acids A鈥揓, 1鈥?b>10) were isolated from the stems of Kadsura coccinea. Except for 10, these compounds feature a rearranged lanostane skeleton with a 6/6/5/6 tetracyclic ring system, and compounds 1 and 2 are the first examples of 2,3-seco-6/6/5/6-fused tetracyclic triterpenoids. Their structures were established primarily by spectroscopic and spectrometric methods. Additionally, the absolute configuration of 3 was determined by single-crystal X-ray diffraction. Several of the compounds isolated were tested for their anti-HIV-1 and cytotoxic activities.