文摘
In the presence of 1.1 equiv of PhMe2Si-Bpin, 5 equiv of CsF, and 20 mol % of TsOH路H2O, precursors of N-Boc-imines can be converted into the corresponding 伪-aryl or 伪-alkenyl glycine derivatives under gaseous CO2 in moderate-to-high yields with a single operation. 伪-Isobutenyl glycine thus obtained can be further derivatized into various types of 伪-amino acids including N-Boc-leucine, serine, and glycine derivatives in short steps.