Systematic Investigations of Different Cytosine Modifications on CpG Dinucleotide Sequences: The Effects on the B-Z Transition

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• 作者：Shaoru Wang ; Yuelin Long ; Jiaqi Wang ; Yushu Ge ; Pu Guo ; Yi Liu ; Tian Tian ; Xiang Zhou
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：January 8, 2014
• 年：2014
• 卷：136
• 期：1
• 页码：56-59
• 全文大小：290K
• ISSN：1520-5126

文摘

We have first demonstrated the distinctive effects of three newly reported epigenetic modifications, including 5hmC, 5fC, and 5caC, on B-Z transition of CpG dinucleotide DNAs. We have performed detailed assays and compared their effects. We further studied the regulation of B-Z transition of CpG dinucleotide dodecamers by alternating oxidation and alternating reduction.