Highly Enantio- and Diastereoselective Vinylogous Aldol Reaction by LiCl-Assisted BINOL鈥揟itanium Species

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• 作者：Guowei Wang ; Baomin Wang ; Shuai Qi ; Jinfeng Zhao ; Yuhan Zhou ; Jingping Qu
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：June 1, 2012
• 年：2012
• 卷：14
• 期：11
• 页码：2734-2737
• 全文大小：236K
• 年卷期：v.14,no.11(June 1, 2012)
• ISSN：1523-7052

文摘

The first highly enantio- and diastereoselective vinylogous aldol reaction between propionyl acetate-derived Brassard鈥檚 diene and aldehydes was accomplished by titanium鈥搇ithium combined Lewis acid, affording 未-hydroxy-纬-methyl-尾-methoxy acrylates. This methodology was utilized in convenient and concise construction of the polypropionate moiety in cystothiazole A and melithiazole C.