Label-Free Electronic Detection of DNA Using Simple Double-Walled Carbon Nanotube Resistors

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• 作者：Xiaochen Dong ; Dongliang Fu ; Yanping Xu ; Jinquan Wei ; Yumeng Shi ; Peng Chen ; Lain-Jong Li
• 刊名：Journal of Physical Chemistry C
• 出版年：2008
• 出版时间：July 3, 2008
• 年：2008
• 卷：112
• 期：26
• 页码：9891 - 9895
• 全文大小：1182K
• 年卷期：v.112,no.26(July 3, 2008)
• ISSN：1932-7455

文摘

Label-free electrical detection of DNA hybridization using resistive sensing devices based on drop-casted doubled-walled carbon nanotube (DWNT) networks and as-grown films is presented. Sensitive, selective, and reliable detection of DNA hybridization is achieved by simple two-terminal measurements, which is suitable for the hand-held type of device applications. Our approach is able to detect DNA concentrations ranging from 50 to 500 nM. Utilizing location-selective capping by photoresists, we designed experiments to reveal the sensing mechanism and found that the carbon nanotube (CNT)−metal junction may not play a dominant role in sensing as it does in single-walled carbon nanotube-based transistor devices. A charge-transfer model is proposed to explain the detection mechanism.