Multifunctional Phosphate-Based Inorganic鈥揙rganic Hybrid Nanoparticles
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- 作者：Joachim G. Heck ; Joanna Napp ; Sara Simonato ; Jens M枚llmer ; Marcus Lange ; Holger M. Reichardt ; Reiner Staudt ; Frauke Alves ; Claus Feldmann
- 刊名：Journal of the American Chemical Society
- 出版年：2015
- 出版时间：June 17, 2015
- 年：2015
- 卷：137
- 期：23
- 页码：7329-7336
- 全文大小：547K
- ISSN：1520-5126
文摘
Phosphate-based inorganic鈥搊rganic hybrid nanoparticles (IOH-NPs) with the general composition [M]2+[Rfunction(O)PO3]2鈥?/sup> (M = ZrO, Mg2O; R = functional organic group) show multipurpose and multifunctional properties. If [Rfunction(O)PO3]2鈥?/sup> is a fluorescent dye anion ([RdyeOPO3]2鈥?/sup>), the IOH-NPs show blue, green, red, and near-infrared fluorescence. This is shown for [ZrO]2+[PUP]2鈥?/sup>, [ZrO]2+[MFP]2鈥?/sup>, [ZrO]2+[RRP]2鈥?/sup>, and [ZrO]2+[DUT]2鈥?/sup> (PUP = phenylumbelliferon phosphate, MFP = methylfluorescein phosphate, RRP = resorufin phosphate, DUT = Dyomics-647 uridine triphosphate). With pharmaceutical agents as functional anions ([RdrugOPO3]2鈥?/sup>), drug transport and release of anti-inflammatory ([ZrO]2+[BMP]2鈥?/sup>) and antitumor agents ([ZrO]2+[FdUMP]2鈥?/sup>) with an up to 80% load of active drug is possible (BMP = betamethason phosphate, FdUMP = 5鈥?fluoro-2鈥?deoxyuridine 5鈥?monophosphate). A combination of fluorescent dye and drug anions is possible as well and shown for [ZrO]2+[BMP]2鈥?/sup>0.996[DUT]2鈥?/sup>0.004. Merging of functional anions, in general, results in [ZrO]2+([RdrugOPO3]1鈥?i>x[RdyeOPO3]x)2鈥?/sup> nanoparticles and is highly relevant for theranostics. Amine-based functional anions in [MgO]2+[RaminePO3]2鈥?/sup> IOH-NPs, finally, show CO2 sorption (up to 180 mg g鈥?) and can be used for CO2/N2 separation (selectivity up to 伪 = 23). This includes aminomethyl phosphonate [AMP]2鈥?/sup>, 1-aminoethyl phosphonate [1AEP]2鈥?/sup>, 2-aminoethyl phosphonate [2AEP]2鈥?/sup>, aminopropyl phosphonate [APP]2鈥?/sup>, and aminobutyl phosphonate [ABP]2鈥?/sup>. All [M]2+[Rfunction(O)PO3]2鈥?/sup> IOH-NPs are prepared via noncomplex synthesis in water, which facilitates practical handling and which is optimal for biomedical application. In sum, all IOH-NPs have very similar chemical compositions but can address a variety of different functions, including fluorescence, drug delivery, and CO2 sorption.