Silicon Nanoparticles as Hyperpolarized Magnetic Resonance Imaging Agents

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• 作者：Jacob W. Aptekar ; Maja C. Cassidy ; Alexander C. Johnson ; Robert A. Barton ; Menyoung Lee ; Alexander C. Ogier ; Chinh Vo ; Melis N. Anahtar ; Yin Ren ; Sangeeta N. Bhatia ; Chandrasekhar Ramanathan ; David G. Cory ; Alison L. Hill ; Ross W. Mair ; Matthew S. Rosen ; Ronald L. Walsworth ; Charles M. Marcus
• 刊名：ACS Nano
• 出版年：2009
• 出版时间：December 22, 2009
• 年：2009
• 卷：3
• 期：12
• 页码：4003-4008
• 全文大小：352K
• 年卷期：0
• ISSN：1936-086X

文摘

Magnetic resonance imaging of hyperpolarized nuclei provides high image contrast with little or no background signal. To date, in vivo applications of prehyperpolarized materials have been limited by relatively short nuclear spin relaxation times. Here, we investigate silicon nanoparticles as a new type of hyperpolarized magnetic resonance imaging agent. Nuclear spin relaxation times for a variety of Si nanoparticles are found to be remarkably long, ranging from many minutes to hours at room temperature, allowing hyperpolarized nanoparticles to be transported, administered, and imaged on practical time scales. Additionally, we demonstrate that Si nanoparticles can be surface functionalized using techniques common to other biologically targeted nanoparticle systems. These results suggest that Si nanoparticles can be used as a targetable, hyperpolarized magnetic resonance imaging agent with a large range of potential applications.