One-Pot Synthesis of Keto Thioethers by Palladium/Gold-Catalyzed Click and Pinacol Reactions

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• 作者：Alban Cadu ; Rahul A. Watile ; Srijit Biswas ; Andreas Orthaber ; Per J. R. Sj枚berg ; Joseph S. M. Samec
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 7, 2014
• 年：2014
• 卷：16
• 期：21
• 页码：5556-5559
• 全文大小：349K
• ISSN：1523-7052

文摘

An atom-efficient synthesis of keto thioethers was devised via tandem gold/palladium catalysis. The reaction proceeds through a regioselective thiol attack at the 尾-position of the alcohol, followed by an alkyl, aryl, or benzyl 1,2-shift. Both acyclic and cyclic systems were studied, in the latter case leading to the ring expansion of cyclic substrates.