Transcutaneous Glucose Sensing by Surface-Enhanced Spatially Offset Raman Spectroscopy in a Rat Model

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• 作者：Jonathan M. Yuen ; Nilam C. Shah ; Joseph T. Walsh ; Jr. ; Matthew R. Glucksberg ; Richard P. Van Duyne
• 刊名：Analytical Chemistry
• 出版年：2010
• 出版时间：October 15, 2010
• 年：2010
• 卷：82
• 期：20
• 页码：8382-8385
• 全文大小：205K
• 年卷期：v.82,no.20(October 15, 2010)
• ISSN：1520-6882

文摘

This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague−Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.