A General Modular Method of Azaindole and Thienopyrrole Synthesis via Pd-Catalyzed Tandem Couplings of gem-Dichloroolefins

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• 作者：Yuan-Qing Fang ; Josephine Yuen ; Mark Lautens
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：July 6, 2007
• 年：2007
• 卷：72
• 期：14
• 页码：5152 - 5160
• 全文大小：293K
• 年卷期：v.72,no.14(July 6, 2007)
• ISSN：1520-6904

文摘

A palladium-catalyzed reaction of gem-dichloroolefins and a boronic acid via a tandem intramolecularC-N and intermolecular Suzuki coupling process gave corresponding substituted azaindoles orthienopyrroles. This method is a very modular protocol to synthesize all four isomers of azaindole andtwo isomers of thienopyrroles in good to excellent yield.