Multifunctional Mercapto-tacrine Derivatives for Treatment of Age-Related Neurodegenerative Diseases
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- 作者：Yue Wang ; Xin-Lei Guan ; Peng-Fei Wu ; Can-Ming Wang ; Hui Cao ; Lei Li ; Xiao-Juan Guo ; Fang Wang ; Na Xie ; Feng-Chao Jiang ; Jian-Guo Chen
- 刊名：Journal of Medicinal Chemistry
- 出版年：2012
- 出版时间：April 12, 2012
- 年：2012
- 卷：55
- 期：7
- 页码：3588-3592
- 全文大小：325K
- 年卷期：v.55,no.7(April 12, 2012)
- ISSN：1520-4804
文摘
Cooperating mercapto groups with tacrine in a single molecular, novel multifunctional compounds have been designed and synthesized. These mercapto-tacrine derivatives displayed a synergistic pharmacological profile of long-term potentiation enhancement, cholinesterase inhibition, neuroprotection, and less hepatotoxicity, emerging as promising molecules for the therapy of age-related neurodegenerative diseases.