Proteolytic Activity of Cu(II) Complex of 1-Oxa-4,7,10-triazacyclododecane

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• 作者：Seung Woo Jang ; Junghun Suh
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：February 7, 2008
• 年：2008
• 卷：10
• 期：3
• 页码：481 - 484
• 全文大小：84K
• 年卷期：v.10,no.3(February 7, 2008)
• ISSN：1523-7052

文摘

Proteolytic activity of the Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane (oxacyclen) was compared with that of the Cu(II) complex of1,4,7,10-tetraazacyclododecane by using albumin, -globulin, and myoglobin as substrates. Values of k_cat/K_m were greater for Cu(II)oxacyclenby 40-80 times. The enhanced activity is attributed to the increased Lewis acidity of Cu(II) due to substitution of one nitrogen donor atom withoxygen.