Discrimination of Escherichia coli Strains using Glycan Cantilever Array Sensors
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- 作者：Andreas Mader ; Kathrin Gruber ; Riccardo Castelli ; Bianca A. Hermann ; Peter H. Seeberger ; Joachim O. R盲dler ; Madeleine Leisner
- 刊名：Nano Letters
- 出版年：2012
- 出版时间：January 11, 2012
- 年：2012
- 卷：12
- 期：1
- 页码：420-423
- 全文大小：224K
- 年卷期：v.12,no.1(January 11, 2012)
- ISSN：1530-6992
文摘
Carbohydrate-based sensors, that specifically detect sugar binding molecules or cells, are increasingly important in medical diagnostic and drug screening. Here we demonstrate that cantilever arrays functionalized with different mannosides allow the real-time detection of several Escherichia coli strains in solution. Cantilever deflection is thereby dependent on the bacterial strain studied and the glycan used as the sensing molecule. The cantilevers exhibit specific and reproducible deflection with a sensitivity range over four orders of magnitude.