Reaction Control of the Robinson Annelation by Pressure and Temperature Manipulation under Supercritical CO2 Conditions
详细信息 查看全文
- 作者：Hajime Kawanami ; Keiichiro Matsushima ; and Yutaka Ikushima
- 刊名：Industrial & Engineering Chemistry Research
- 出版年：2005
- 出版时间：December 7, 2005
- 年：2005
- 卷：44
- 期：25
- 页码：9561 - 9564
- 全文大小：83K
- 年卷期：v.44,no.25(December 7, 2005)
- ISSN：1520-5045
文摘
Robinson annelation under supercritical CO2 in the presence of various metal oxide catalystswithout any organic solvent was studied to synthesize fused polycyclic compounds such as theseries of steroid compounds. Under constant pressure and temperature, the reaction would havea limitation in the yield of desired product 8a-methyl-3,4,8,8a-tetrahydro-2H,7H-naphthalene-1,6-dione (5a) up to 57%. To improve the reaction yield of the product, we developed the newmethod that the pressure and temperature manipulation in one pot by using sub- andsupercritical CO2 can be achieved successfully to obtain 5a in high yield (95%) and high selectivity(95%) without any modifications of the catalysts. This simple method could be applied for variousketones and various catalysts to synthesize fused polycyclic compounds.