Functionalized Graphene-Coated Cobalt Nanoparticles for Highly Efficient Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Analysis

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• 作者：Hideya Kawasaki ; Keisuke Nakai ; Ryuichi Arakawa ; Evagelos K. Athanassiou ; Robert N. Grass ; Wendelin J. Stark
• 刊名：Analytical Chemistry
• 出版年：2012
• 出版时间：November 6, 2012
• 年：2012
• 卷：84
• 期：21
• 页码：9268-9275
• 全文大小：444K
• 年卷期：v.84,no.21(November 6, 2012)
• ISSN：1520-6882

文摘

Graphene-coated cobalt nanoparticles surface-functionalized with benzylamine groups (CoC鈥揘H₂ nanomagnets) were shown to effectively enrich analytes for surface-assisted laser desorption/ionization mass spectrometry (affinity SALDI-MS) analysis. These CoC鈥揘H₂ nanomagnets are highly suited for use with affinity SALDI-MS because their mean diameter of 30 nm, high specific surface area of 15 m² g^鈥?, and high-strength saturation magnetization of 158 emu g^鈥? led to efficient extraction of analytes by magnetic separation, which in turn enabled excellent SALDI-MS performance. Surface modification of CoC nanomagnets with benzylamine groups increased the yield of peptide ions and decreased fragmentation of benzylpyridinium ions, so-called 鈥渢hermometer ions鈥?formed through soft ionization. The CoC鈥揘H₂ nanomagnets were used to extract perfluorooctanesulfonate from large volumes of aqueous solutions by magnetic separation, which was identified directly by SALDI-MS analysis with high sensitivity even at the sub-part-per-trillion level (0.1 ng/L). The applicability of CoC鈥揘H₂ nanomagnets in conjunction with SALDI-MS for the enrichment and detection of pentachlorophenol, bisphenol A, and polyfluorinated compounds (PFCs) with varying chain length, which are environmentally significant compounds, as well as small drugs, was also evaluated.