Eudesmane-Type Sesquiterpenoid and Guaianolides from Kandelia candel in a Screening Program for Compounds to Overcome TRAIL Resistance
详细信息 查看全文
- 作者：Tomohiro Minakawa ; Kazufumi Toume ; Midori A. Arai ; Samir K. Sadhu ; Firoj Ahmed ; Masami Ishibashi
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：August 24, 2012
- 年：2012
- 卷：75
- 期：8
- 页码：1431-1435
- 全文大小：294K
- 年卷期：v.75,no.8(August 24, 2012)
- ISSN：1520-6025
文摘
In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (1), three new guaianolides, mehirugins A鈥揅 (2鈥?b>4), and two known guaianolides (5 and 6) were isolated from a MeOH extract of Kandelia candel leaves. Compounds 1 and 3鈥?b>6 in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.