Cerasoidine, a Bis-aporphine Alkaloid Isolated from Polyalthia cerasoides during Screening for Wnt Signal Inhibitors

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• 作者：Takumi Shono ; Naoki Ishikawa ; Kazufumi Toume ; Midori A. Arai ; Hyuma Masu ; Takashi Koyano ; Thaworn Kowithayakorn ; Masami Ishibashi
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：August 26, 2016
• 年：2016
• 卷：79
• 期：8
• 页码：2083-2088
• 全文大小：337K
• 年卷期：0
• ISSN：1520-6025

文摘

A new bis-aporphine alkaloid, cerasoidine (1), was isolated from the root extract of Polyalthia cerasoides together with the known bis-aporphine bidebiline E (2) during screening for compounds with Wnt signal inhibitory activities. The structure of cerasoidine (1) was established by X-ray analysis and shown by chiral HPLC analyses and electronic circular dichroism to be a 57:43 mixture of R(−)- and S(+)-atropisomers. Bidebiline E (2) exhibited inhibition of transcriptional activity of TCF/β-catenin with an IC₅₀ value of 20.2 μM and was also found to inhibit Wnt signaling by decreasing nuclear β-catenin.