Moromycins A and B, Isolation and Structure Elucidation of C-Glycosylangucycline-Type Antibiotics from Streptomyces sp. KY002

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• 作者：Mohamed S. Abdelfattah ; Madan Kumar Kharel ; John Andrew Hitron ; Irfan Baig ; Jü ; rgen Rohr
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：September 26, 2008
• 年：2008
• 卷：71
• 期：9
• 页码：1569-1573
• 全文大小：143K
• 年卷期：v.71,no.9(September 26, 2008)
• ISSN：1520-6025

文摘

Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.