Enzymatic Total Synthesis of Rabelomycin, an Angucycline Group Antibiotic

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• 作者：Madan Kumar Kharel ; Pallab Pahari ; Hui Lian ; Jrgen Rohr
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：June 18, 2010
• 年：2010
• 卷：12
• 期：12
• 页码：2814-2817
• 全文大小：173K
• 年卷期：v.12,no.12(June 18, 2010)
• ISSN：1523-7052

文摘

A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.