Pyridone Alkaloids from a Marine-Derived Fungus, Stagonosporopsis cucurbitacearum, and Their Activities against Azole-Resistant Candida albicans
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- 作者：Asami Haga ; Hiroki Tamoto ; Masahiro Ishino ; Eriko Kimura ; Takashi Sugita ; Kaoru Kinoshita ; Kunio Takahashi ; Motoo Shiro ; Kiyotaka Koyama
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：April 26, 2013
- 年：2013
- 卷：76
- 期：4
- 页码：750-754
- 全文大小：245K
- 年卷期：v.76,no.4(April 26, 2013)
- ISSN：1520-6025
文摘
Four new 4-hydroxy-2-pyridone alkaloids, didymellamides A鈥揇 (1鈥?b>4), were isolated from the marine-derived fungus Stagonosporopsis cucurbitacearum. The structures of 1鈥?b>4 were elucidated from spectroscopic data (NMR, MS, and IR), and the absolute configuration of 1 was determined by X-ray diffraction analysis. Didymellamide A (1) exhibited antifungal activity against azole-resistant Candida albicans.