Formation of Bone-like Nanocrystalline Apatite Using Self-Assembled Liquid Crystals
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- 作者：Wenxiao He ; Per Kjellin ; Fredrik Currie ; Paul Handa ; Christopher S. Knee ; Johan Bielecki ; L. Reine Wallenberg ; Martin Andersson
- 刊名：Chemistry of Materials
- 出版年：2012
- 出版时间：March 13, 2012
- 年：2012
- 卷：24
- 期：5
- 页码：892-902
- 全文大小：1270K
- 年卷期：v.24,no.5(March 13, 2012)
- ISSN：1520-5002
文摘
A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 卤 1.4 nm and specific surface area (SSA) in the range of 150鈥?70 m2/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Q water, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP 鈥?PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were characterized by X-ray diffraction, conventional and high-resolution transmission electron microscopy, nitrogen adsorption, thermogravimetry with infrared-coupled analysis, and Raman spectroscopy. The PCA formed using the LC鈥揳ging route presented bone-resembling features, such as Ca2+ and OH鈥?/sup> deficiency, CO32- substitution, poor crystallinity, and ultrahigh SSA of 356 m2/g. The resulting particles were compared to hydroxyapatite synthesized via a conventional water-based precipitation method. The LC鈥揳ging route exhibited excellent controllability over the CaP crystallization, which enabled facile tailoring of the resulting material properties for different types of application.