Isolation and Structures of Erylosides from the Carribean Sponge Erylus goffrilleri

详细信息    查看全文

• 作者：Shamil Sh. Afiyatullov ; Anatoly I. Kalinovsky ; Alexandr S. Antonov ; Ludmila P. Ponomarenko ; Pavel S. Dmitrenok ; Dmitry L. Aminin ; Vladimir B. Krasokhin ; Valentina M. Nosova ; Alexandr V. Kisin
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：70
• 期：12
• 页码：1871 - 1877
• 全文大小：113K
• 年卷期：v.70,no.12(December 2007)
• ISSN：1520-6025

文摘

Eight new triterpene glycosides, erylosides R (<B>1), S (2), T (3), U (4), F₅−F₇ (5–7), and V (8), were isolated from the sponge Erylus goffrilleri collected near Arresife-Seko Reef (Cuba). Structures of 1 and 2 were determined as the corresponding monosides having aglycons related to penasterol with additional oxidation and methylation patterns in their side chains. Eryloside T (3) was structurally identified as the Δ⁷-isomer of 1, containing an unusual (14→9)-lactone ring in the tetracyclic aglycon moiety, and eryloside U (4) was shown to be the 7,8-epoxide of 3. Erylosides F₅−F₇ (5–7) and V (8) contain new variants of carbohydrate chains with two (5–7) and three (8) sugar units, respectively.