Biosynthetic Convergence of Salinosporamides A and B in the Marine Actinomycete Salinispora tropica

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• 作者：Laura L. Beer ; Bradley S. Moore
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：March 1, 2007
• 年：2007
• 卷：9
• 期：5
• 页码：845 - 848
• 全文大小：74K
• 年卷期：v.9,no.5(March 1, 2007)
• ISSN：1523-7052

文摘

Feeding experiments with stable isotopes established that the potent 20S-proteasome inhibitors salinosporamide A and B are biosynthesizedin the marine bacterium Salinispora tropica from three biosynthetic building blocks, namely, acetate, -hydroxy-2'-cyclohexenylalanine, andeither butyrate or a tetrose-derived chlorinated molecule. The unexpected observation that the chlorinated four-carbon residue in salinosporamideA is derived from a different metabolic origin than the non-chlorinated four-carbon unit in salinosporamide B is suggestive of a convergentbiosynthesis to these two anticancer natural products.