DNA Condensation Induced by Ruthenium(II) Polypyridyl Complexes [Ru(bpy)2(PIPSH)]2+ and [Ru(bpy)2(PIPNH)]2+
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- 作者：Bin Sun ; Jing-Xin Guan ; Li Xu ; Bo-Le Yu ; Long Jiang ; Jun-Feng Kou ; Li Wang ; Xi-Dong Ding ; Hui Chao ; Liang-Nian Ji
- 刊名：Inorganic Chemistry
- 出版年：2009
- 出版时间：June 1, 2009
- 年：2009
- 卷：48
- 期：11
- 页码：4637-4639
- 全文大小：766K
- 年卷期：v.48,no.11(June 1, 2009)
- ISSN：1520-510X
文摘
Two novel DNA-intercalating ruthenium(II) complexes, [Ru(bpy)2(PIPSH)]2+ and [Ru(bpy)2(PIPNH)]2+, have been synthesized and characterized. Gel retardation assay, atomic force microscopy, and dynamic light scattering studies show that both complexes can induce the condensation of originally circular plasmid pBR322 DNA to particulate structures under neutral conditions.